Protein interactions for CALR - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CALR
Gene descriptionⁱ Full gene name according to HGNC.	Calreticulin
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Human disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Glycosylation (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.16
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Endoplasmic reticulum
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

Highlight:

Off

Subcell location

Predicted location

Tissue specificity

Protein class

Filter menu »

e.g. Brain enriched, Localized to mitochondria, Non-specific - Glycosylation

Field

Cluster

Pathway

Number of interactions:

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
APP	Physical association	High	0.74	312
GABARAP	Direct interaction	High	0.71	40
MTNR1A	Physical association	High	0.66	7
SMARCB1	Physical association	Medium	0.59	33
PDIA3	Physical association	Medium	0.59	8
C11orf65	Physical association	Medium	0.56	8
C1orf216	Physical association	Medium	0.56	69
C6orf58	Physical association	Medium	0.56	5
CNOT3	Physical association	Medium	0.56	10
DNASE1L1	Physical association	Medium	0.56	10
DRC7	Physical association	Medium	0.56	4
EGFL8	Physical association	Medium	0.56	8
EPCAM	Physical association	Medium	0.56	5
EVA1B	Physical association	Medium	0.56	6
FAHD2A	Physical association	Medium	0.56	3
FUT2	Physical association	Medium	0.56	3
GJA5	Physical association	Medium	0.56	27
GNAO1	Physical association	Medium	0.56	8
GSC2	Physical association	Medium	0.56	46
HSD3B1	Physical association	Medium	0.56	8
IDH1	Physical association	Medium	0.56	8
ISY1	Physical association	Medium	0.56	13
KLRC1	Physical association	Medium	0.56	42
LGALS1	Physical association	Medium	0.56	9
MAGEA2	Physical association	Medium	0.56	25
MAGEA2B	Physical association	Medium	0.56	25
MAVS	Physical association	Medium	0.56	25
MMAB	Physical association	Medium	0.56	4
MYBPHL	Physical association	Medium	0.56	10
MYNN	Physical association	Medium	0.56	12
NXPE1	Physical association	Medium	0.56	5
PIAS4	Physical association	Medium	0.56	35
POC1A	Physical association	Medium	0.56	8
PPEF1	Physical association	Medium	0.56	4
PRAM1	Physical association	Medium	0.56	17
PSAT1	Physical association	Medium	0.56	4
PSMC4	Physical association	Medium	0.56	10
PSMD2	Physical association	Medium	0.56	25
PYGO1	Physical association	Medium	0.56	5
RAB31	Physical association	Medium	0.56	4
RAB3C	Physical association	Medium	0.56	7
RAP1B	Physical association	Medium	0.56	6
RASSF2	Physical association	Medium	0.56	15
RBM17	Physical association	Medium	0.56	21
RBM5	Physical association	Medium	0.56	12
SGTB	Physical association	Medium	0.56	96
SLC25A11	Physical association	Medium	0.56	7
SP6	Physical association	Medium	0.56	9
SPATA17	Physical association	Medium	0.56	4
SPRED2	Physical association	Medium	0.56	38
TAF1B	Physical association	Medium	0.56	4
TDO2	Physical association	Medium	0.56	19
THAP7	Physical association	Medium	0.56	47
THBS3	Physical association	Medium	0.56	3
TPX2	Physical association	Medium	0.56	8
TRNAU1AP	Physical association	Medium	0.56	4
TUBB	Physical association	Medium	0.56	17
USP12	Physical association	Medium	0.56	7
ZHX1-C8orf76	Physical association	Medium	0.56	13
MBL2	Direct interaction	Medium	0.54	9
HSPB1	Physical association	Medium	0.51	137
TCTN2	Physical association	Medium	0.51	8
TAP1	Physical association	Medium	0.5	17
Show allShow less

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
CALR is not a metabolic protein