Protein interactions for ZNF587 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZNF587
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger protein 587
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Stomach - Proteolysis (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.24
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm In addition localized to the Nucleoli
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ

Highlight:

Off

Subcell location

Predicted location

Tissue specificity

Protein class

Filter menu »

e.g. Brain enriched, Localized to mitochondria, Stomach - Proteolysis

Field

Cluster

Pathway

Number of interactions:

102

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
CEP44	Physical association	High	0.72	40
CEP70	Physical association	High	0.72	196
FSD2	Physical association	High	0.72	73
KRT40	Physical association	High	0.72	288
KRTAP10-5	Physical association	High	0.72	115
KRTAP10-7	Physical association	High	0.72	239
KRTAP10-8	Physical association	High	0.72	325
KRTAP10-9	Physical association	High	0.72	182
KRTAP5-9	Physical association	High	0.72	166
MDFI	Physical association	High	0.72	277
PNMA2	Physical association	High	0.72	29
PRPF31	Physical association	High	0.72	118
STX11	Physical association	High	0.72	80
TNS2	Physical association	High	0.72	70
TRAF1	Physical association	High	0.72	166
TRIM41	Physical association	High	0.72	108
TRIM54	Physical association	High	0.72	151
ZBTB8A	Physical association	High	0.72	58
AQP6	Physical association	Medium	0.56	264
ASB15	Physical association	Medium	0.56	10
ASB6	Physical association	Medium	0.56	13
AXIN2	Physical association	Medium	0.56	36
BEGAIN	Physical association	Medium	0.56	29
C17orf50	Physical association	Medium	0.56	6
CARD10	Physical association	Medium	0.56	83
CARD9	Physical association	Medium	0.56	52
CCDC125	Physical association	Medium	0.56	53
CCDC85B	Physical association	Medium	0.56	12
CSRNP1	Physical association	Medium	0.56	9
CYSRT1	Physical association	Medium	0.56	396
DHX57	Physical association	Medium	0.56	18
EFEMP2	Physical association	Medium	0.56	83
FHL3	Physical association	Medium	0.56	103
FHL5	Physical association	Medium	0.56	62
FST	Physical association	Medium	0.56	7
GOLGA2	Physical association	Medium	0.56	349
GOLGA6L9	Physical association	Medium	0.56	177
GOPC	Physical association	Medium	0.56	28
GSC2	Physical association	Medium	0.56	46
HMBOX1	Physical association	Medium	0.56	76
HSF2BP	Physical association	Medium	0.56	223
IGFBP6	Physical association	Medium	0.56	28
IKBKG	Physical association	Medium	0.56	57
IKZF3	Physical association	Medium	0.56	130
INSC	Physical association	Medium	0.56	9
KATNBL1	Physical association	Medium	0.56	31
KPRP	Physical association	Medium	0.56	80
KRT31	Physical association	Medium	0.56	284
KRT38	Physical association	Medium	0.56	57
KRTAP1-1	Physical association	Medium	0.56	150
KRTAP1-3	Physical association	Medium	0.56	140
KRTAP10-10	Physical association	Medium	0.56	18
KRTAP10-11	Physical association	Medium	0.56	31
KRTAP12-2	Physical association	Medium	0.56	97
KRTAP12-3	Physical association	Medium	0.56	117
KRTAP2-3	Physical association	Medium	0.56	9
KRTAP2-4	Physical association	Medium	0.56	77
KRTAP5-7	Physical association	Medium	0.56	50
LDOC1	Physical association	Medium	0.56	82
LRP2BP	Physical association	Medium	0.56	17
LZTS1	Physical association	Medium	0.56	73
MCCD1	Physical association	Medium	0.56	20
MEOX2	Physical association	Medium	0.56	158
MKRN3	Physical association	Medium	0.56	118
MTUS2	Physical association	Medium	0.56	130
MYF5	Physical association	Medium	0.56	18
NDUFB7	Physical association	Medium	0.56	27
NKAPL	Physical association	Medium	0.56	6
NOTCH2NLA	Physical association	Medium	0.56	190
NOTCH2NLC	Physical association	Medium	0.56	178
PBX2	Physical association	Medium	0.56	19
PLSCR1	Physical association	Medium	0.56	43
PRDM14	Physical association	Medium	0.56	41
RUNDC3A	Physical association	Medium	0.56	15
SMYD5	Physical association	Medium	0.56	2
SOX13	Physical association	Medium	0.56	6
SPRED1	Physical association	Medium	0.56	308
SPRY2	Physical association	Medium	0.56	51
SPRY3	Physical association	Medium	0.56	22
SSX2IP	Physical association	Medium	0.56	78
TCF4	Physical association	Medium	0.56	124
TENM4	Physical association	Medium	0.56	7
TFIP11	Physical association	Medium	0.56	179
TRIB3	Physical association	Medium	0.56	54
TRIM23	Physical association	Medium	0.56	142
TRIM27	Physical association	Medium	0.56	232
TRIM36	Physical association	Medium	0.56	8
TRIM37	Physical association	Medium	0.56	31
TSGA10	Physical association	Medium	0.56	54
TXK	Physical association	Medium	0.56	16
VPS52	Physical association	Medium	0.56	83
VWC2	Physical association	Medium	0.56	51
ZBTB43	Physical association	Medium	0.56	21
ZIM2	Physical association	Medium	0.56	26
ZKSCAN8	Physical association	Medium	0.56	14
ZNF286A	Physical association	Medium	0.56	13
ZNF330	Physical association	Medium	0.56	43
ZNF417	Physical association	Medium	0.56	140
ZNF547	Physical association	Medium	0.56	7
ZNF774	Physical association	Medium	0.56	68
ZNF837	Physical association	Medium	0.56	68
ZRANB1	Physical association	Medium	0.56	112
Show allShow less

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
ZNF587 is not a metabolic protein