Protein interactions for NOTCH2NLA - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NOTCH2NLA
Gene descriptionⁱ Full gene name according to HGNC.	Notch 2 N-terminal like A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Testis - Unknown function (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.26
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Secreted to blood

INTERACTION SUMMARYⁱ

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Subcell location

Predicted location

Tissue specificity

Protein class

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e.g. Brain enriched, Localized to mitochondria, Testis - Unknown function

Field

Cluster

Pathway

Number of interactions:

190

View all protein interaction data in IntAct

Interaction	Interaction type	Confidence	MI score	# Interactions
ITGB2	Physical association	High	0.78	21
CHRNG	Physical association	High	0.74	5
LCE1B	Physical association	High	0.74	69
NEU2	Physical association	High	0.72	2
PRPF31	Physical association	High	0.72	118
ADCK5	Physical association	High	0.67	1
ALPI	Physical association	High	0.67	3
BLCAP	Physical association	High	0.67	14
CATSPER1	Physical association	High	0.67	95
CCER1	Physical association	High	0.67	10
CRCT1	Physical association	High	0.67	46
CTSZ	Physical association	High	0.67	16
GATA2	Physical association	High	0.67	24
GNE	Physical association	High	0.67	12
HBZ	Physical association	High	0.67	18
HSBP1	Physical association	High	0.67	15
HSPBP1	Physical association	High	0.67	5
IL2RG	Physical association	High	0.67	6
KRTAP5-6	Physical association	High	0.67	73
LCE3E	Physical association	High	0.67	46
LNX1	Physical association	High	0.67	333
MXD3	Physical association	High	0.67	10
NECTIN3	Physical association	High	0.67	9
NPPB	Physical association	High	0.67	7
PDE9A	Physical association	High	0.67	14
PLSCR4	Physical association	High	0.67	45
PTPN23	Physical association	High	0.67	13
PVR	Physical association	High	0.67	52
RAB3IL1	Physical association	High	0.67	24
RCHY1	Physical association	High	0.67	17
SLC22A23	Physical association	High	0.67	3
SLC25A10	Physical association	High	0.67	6
SMCP	Physical association	High	0.67	67
SMOC1	Physical association	High	0.67	3
SNAI1	Physical association	High	0.67	29
SPRY1	Physical association	High	0.67	59
THAP7	Physical association	High	0.67	47
THEMIS2	Physical association	High	0.67	1
TSPAN4	Physical association	High	0.67	30
UXT	Physical association	High	0.67	21
YIPF3	Physical association	High	0.67	13
ACY3	Physical association	Medium	0.56	15
ADAMTSL3	Physical association	Medium	0.56	13
ALDH3B1	Physical association	Medium	0.56	15
AQP1	Physical association	Medium	0.56	106
AQP5	Physical association	Medium	0.56	5
ARID3A	Physical association	Medium	0.56	10
ASPSCR1	Physical association	Medium	0.56	9
ATG9A	Physical association	Medium	0.56	11
C11orf87	Physical association	Medium	0.56	18
CARHSP1	Physical association	Medium	0.56	11
CD164	Physical association	Medium	0.56	3
CERK	Physical association	Medium	0.56	19
CHCHD3	Physical association	Medium	0.56	37
CHDH	Physical association	Medium	0.56	2
CHIC2	Physical association	Medium	0.56	53
CHRD	Physical association	Medium	0.56	40
CLDN2	Physical association	Medium	0.56	16
CLEC18A	Physical association	Medium	0.56	5
COL8A1	Physical association	Medium	0.56	51
CRACR2A	Physical association	Medium	0.56	31
CSF1	Physical association	Medium	0.56	7
CST2	Physical association	Medium	0.56	7
CST9L	Physical association	Medium	0.56	6
CTSG	Physical association	Medium	0.56	4
DHRS1	Physical association	Medium	0.56	25
DMRT3	Physical association	Medium	0.56	65
DNAL4	Physical association	Medium	0.56	12
DOCK2	Physical association	Medium	0.56	36
EFNA3	Physical association	Medium	0.56	4
EIF4E2	Physical association	Medium	0.56	32
FAAH	Physical association	Medium	0.56	1
FAM124B	Physical association	Medium	0.56	24
FARS2	Physical association	Medium	0.56	56
FASLG	Physical association	Medium	0.56	28
FBXW5	Physical association	Medium	0.56	21
FOXB1	Physical association	Medium	0.56	5
FRS3	Physical association	Medium	0.56	77
GABRD	Physical association	Medium	0.56	3
GARIN6	Physical association	Medium	0.56	19
GEM	Physical association	Medium	0.56	88
GFOD1	Physical association	Medium	0.56	17
GIP	Physical association	Medium	0.56	4
GLP1R	Physical association	Medium	0.56	10
GLRX3	Physical association	Medium	0.56	78
GLYAT	Physical association	Medium	0.56	2
GNAI2	Physical association	Medium	0.56	10
GSTP1	Physical association	Medium	0.56	21
GTF3C5	Physical association	Medium	0.56	6
HCK	Physical association	Medium	0.56	17
HPCAL1	Physical association	Medium	0.56	31
HSD3B7	Physical association	Medium	0.56	42
HSPA12B	Physical association	Medium	0.56	10
HSPD1	Physical association	Medium	0.56	35
IFI30	Physical association	Medium	0.56	3
INPP5D	Physical association	Medium	0.56	9
JOSD1	Physical association	Medium	0.56	24
KCTD15	Physical association	Medium	0.56	2
KLHL38	Physical association	Medium	0.56	72
KLK8	Physical association	Medium	0.56	13
KRT20	Physical association	Medium	0.56	32
KRT83	Physical association	Medium	0.56	31
KRTAP10-11	Physical association	Medium	0.56	31
KRTAP10-5	Physical association	Medium	0.56	115
KRTAP10-7	Physical association	Medium	0.56	239
KRTAP10-8	Physical association	Medium	0.56	325
KRTAP10-9	Physical association	Medium	0.56	182
KRTAP12-2	Physical association	Medium	0.56	97
KRTAP12-4	Physical association	Medium	0.56	41
KRTAP13-3	Physical association	Medium	0.56	58
KRTAP26-1	Physical association	Medium	0.56	73
KRTAP3-1	Physical association	Medium	0.56	61
KRTAP4-11	Physical association	Medium	0.56	61
KRTAP4-12	Physical association	Medium	0.56	74
KRTAP4-2	Physical association	Medium	0.56	102
KRTAP4-7	Physical association	Medium	0.56	11
KRTAP5-9	Physical association	Medium	0.56	166
KRTAP9-2	Physical association	Medium	0.56	123
KRTAP9-4	Physical association	Medium	0.56	25
LCE2D	Physical association	Medium	0.56	51
LCE3C	Physical association	Medium	0.56	46
LIN7A	Physical association	Medium	0.56	12
LMO2	Physical association	Medium	0.56	61
LONRF3	Physical association	Medium	0.56	8
LRCH4	Physical association	Medium	0.56	14
LRFN4	Physical association	Medium	0.56	8
MAPKBP1	Physical association	Medium	0.56	48
MATN3	Physical association	Medium	0.56	5
MRGBP	Physical association	Medium	0.56	14
MRPL40	Physical association	Medium	0.56	7
MTA1	Physical association	Medium	0.56	23
NAB2	Physical association	Medium	0.56	62
NAXD	Physical association	Medium	0.56	13
NECTIN2	Physical association	Medium	0.56	10
NMU	Physical association	Medium	0.56	14
NPBWR2	Physical association	Medium	0.56	15
NPDC1	Physical association	Medium	0.56	27
NUBP2	Physical association	Medium	0.56	10
P2RX4	Physical association	Medium	0.56	6
PCED1A	Physical association	Medium	0.56	3
PCED1B	Physical association	Medium	0.56	1
PCSK5	Physical association	Medium	0.56	10
PID1	Physical association	Medium	0.56	9
PIGS	Physical association	Medium	0.56	11
PLPP2	Physical association	Medium	0.56	4
POMGNT2	Physical association	Medium	0.56	1
PRKAA2	Physical association	Medium	0.56	78
PRPS2	Physical association	Medium	0.56	10
PSMA1	Physical association	Medium	0.56	135
PSMG2	Physical association	Medium	0.56	4
PTPMT1	Physical association	Medium	0.56	25
RAMP3	Physical association	Medium	0.56	7
RET	Physical association	Medium	0.56	5
RGL2	Physical association	Medium	0.56	6
RPS28	Physical association	Medium	0.56	9
RTN4RL1	Physical association	Medium	0.56	5
SCNM1	Physical association	Medium	0.56	148
SDCBP	Physical association	Medium	0.56	240
SELENOM	Physical association	Medium	0.56	10
SEMA4C	Physical association	Medium	0.56	14
SHFL	Physical association	Medium	0.56	26
SLC23A1	Physical association	Medium	0.56	10
SLC25A6	Physical association	Medium	0.56	12
SLC6A20	Physical association	Medium	0.56	8
SMARCE1	Physical association	Medium	0.56	56
SPG7	Physical association	Medium	0.56	17
SPINK2	Physical association	Medium	0.56	6
STK16	Physical association	Medium	0.56	66
TBC1D10C	Physical association	Medium	0.56	3
TEDC2	Physical association	Medium	0.56	6
TLE5	Physical association	Medium	0.56	105
TMEM150A	Physical association	Medium	0.56	4
TMEM231	Physical association	Medium	0.56	7
TMEM41A	Physical association	Medium	0.56	7
TNIP3	Physical association	Medium	0.56	26
TNK2	Physical association	Medium	0.56	12
TRIM27	Physical association	Medium	0.56	232
TRIM42	Physical association	Medium	0.56	112
UTP23	Physical association	Medium	0.56	22
WDR25	Physical association	Medium	0.56	5
XCL2	Physical association	Medium	0.56	5
ZFYVE21	Physical association	Medium	0.56	22
ZNF32	Physical association	Medium	0.56	9
ZNF417	Physical association	Medium	0.56	140
ZNF439	Physical association	Medium	0.56	19
ZNF440	Physical association	Medium	0.56	26
ZNF581	Physical association	Medium	0.56	82
ZNF587	Physical association	Medium	0.56	102
NMUR2	Physical association	Medium	0.49	3
ZNF124	Physical association	Medium	0.49	45
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
NOTCH2NLA is not a metabolic protein